MovDisordV3, Main, Exploration, bibRecord, 001240

25-Hydroxyvitamin D, Vitamin D Receptor Gene Polymorphisms, and Severity of Parkinson's Disease

Identifieur interne : 001240 ( Main/Exploration ); précédent : 001239; suivant : 001241

25-Hydroxyvitamin D, Vitamin D Receptor Gene Polymorphisms, and Severity of Parkinson's Disease

Auteurs : Masahiko Suzuki [Japon] ; Masayuki Yoshioka [Japon] ; Masaya Hashimoto [Japon] ; Maiko Murakami [Japon] ; Keiichi Kawasaki [Japon] ; Miki Noya [Japon] ; Daisuke Takahashi [Japon] ; Mitsuyoshi Urashima [Japon]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0113824

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Vitamine D, Récepteur biologique, Polymorphisme mononucléotide, Protéine liaison.

English descriptors

KwdEn :
- Binding protein, Biological receptor, Nervous system diseases, Parkinson disease, Single nucleotide polymorphism, Vitamin D.

Abstract

We aimed to examine associations among serum 25-hydroxyvitamin D levels, 1,25-dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25-hydroxyvitamin D, 1,25-hydroxyvitamin D, vitamin D receptor polymorphisms, ie, Fok/ (rs10735810), Bsm/ (rs1544410), Cdx2 (rs11568820), Apal (rs7976091), and Taql (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean ± standard deviation levels of 25-hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficient (<20 ng/mL) in 49% of patients. In contrast, 1,25-hydroxyvitamin D levels were considered normal in all patients. Higher circulating 25-hydroxyvitamin D levels were significantly associated with milder Parkinson's disease evaluated by Hoehn & Yahr stage (P = .002) and total Unified Parkinson's Disease Rating Stage (P = .004) even after multivariate adjustment for 8 covariates, including disease duration. However, significant associations were not observed in 1,25-hydroxyvitamin D levels. Under multivariate analysis with 25-hydroxyvitamin D as well as other 8 covariates including disease duration, carriers of vitamin D receptor Fok/CC genotype had a milder form of Parkinson's disease: odds ratio, 0.32; 95% confidence interval, 0.16 to 0.66, P = 0.002. These results suggest that higher 25-hydroxyvitamin D levels and the vitamin D receptor Fok/CC genotype may be independently associated with milder forms of Parkinson's disease. However, significant associations were not observed in 1,25-hydroxyvitamin D levels.

Affiliations:

Japon
Tokyo

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">25-Hydroxyvitamin D, Vitamin D Receptor Gene Polymorphisms, and Severity of Parkinson's Disease</title>
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<author><name sortKey="Noya, Miki" sort="Noya, Miki" uniqKey="Noya M" first="Miki" last="Noya">Miki Noya</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Division of Molecular Epidemiology, Jikei University School of Medicine</s1>
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<author><name sortKey="Takahashi, Daisuke" sort="Takahashi, Daisuke" uniqKey="Takahashi D" first="Daisuke" last="Takahashi">Daisuke Takahashi</name>
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</author>
<author><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Division of Molecular Epidemiology, Jikei University School of Medicine</s1>
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<placeName><settlement type="city">Tokyo</settlement>
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<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Binding protein</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
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<term>Récepteur biologique</term>
<term>Polymorphisme mononucléotide</term>
<term>Protéine liaison</term>
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<front><div type="abstract" xml:lang="en">We aimed to examine associations among serum 25-hydroxyvitamin D levels, 1,25-dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25-hydroxyvitamin D, 1,25-hydroxyvitamin D, vitamin D receptor polymorphisms, ie, Fok/ (rs10735810), Bsm/ (rs1544410), Cdx2 (rs11568820), Apal (rs7976091), and Taql (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean ± standard deviation levels of 25-hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficient (<20 ng/mL) in 49% of patients. In contrast, 1,25-hydroxyvitamin D levels were considered normal in all patients. Higher circulating 25-hydroxyvitamin D levels were significantly associated with milder Parkinson's disease evaluated by Hoehn & Yahr stage (P = .002) and total Unified Parkinson's Disease Rating Stage (P = .004) even after multivariate adjustment for 8 covariates, including disease duration. However, significant associations were not observed in 1,25-hydroxyvitamin D levels. Under multivariate analysis with 25-hydroxyvitamin D as well as other 8 covariates including disease duration, carriers of vitamin D receptor Fok/CC genotype had a milder form of Parkinson's disease: odds ratio, 0.32; 95% confidence interval, 0.16 to 0.66, P = 0.002. These results suggest that higher 25-hydroxyvitamin D levels and the vitamin D receptor Fok/CC genotype may be independently associated with milder forms of Parkinson's disease. However, significant associations were not observed in 1,25-hydroxyvitamin D levels.</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
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<tree><country name="Japon"><noRegion><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name>
</noRegion>
<name sortKey="Hashimoto, Masaya" sort="Hashimoto, Masaya" uniqKey="Hashimoto M" first="Masaya" last="Hashimoto">Masaya Hashimoto</name>
<name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name>
<name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name>
<name sortKey="Noya, Miki" sort="Noya, Miki" uniqKey="Noya M" first="Miki" last="Noya">Miki Noya</name>
<name sortKey="Takahashi, Daisuke" sort="Takahashi, Daisuke" uniqKey="Takahashi D" first="Daisuke" last="Takahashi">Daisuke Takahashi</name>
<name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name>
<name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name>
</country>
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</record>

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	Movement Disorders (revue)
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Movement Disorders (revue)

25-Hydroxyvitamin D, Vitamin D Receptor Gene Polymorphisms, and Severity of Parkinson's Disease

25-Hydroxyvitamin D, Vitamin D Receptor Gene Polymorphisms, and Severity of Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri